Scientific Career
Years | Institution | Level | Department | Field |
|---|---|---|---|---|
2015-present | University of British Columbia | Associate Professor Emeritus | Ophthalmology and Visual Sciences | |
1999-2003 | Emily Carr Institute of Art and Design | Instructor | Visual sciences for fine art students | |
1987-2014 | University of British Columbia | Associate Professor | Ophthalmology and Visual Sciences, Graduate Program in Neuroscience | Electrophysiology, Psychophysics |
1986-1987 | Dalhousie University | Associate Professor | Physiology and Biophysics | Electrophysiology |
1982-1986 | McGill University | Assistant Professor | Aerospace Medical Research Unit, Physiology | Eye movement control |
1979-1981 | McGill University | Postdoctoral Fellow | Aerospace Medical Research Unit, Physiology | Visual-vestibular plasticity |
1973-1978 | Dalhouse University | M.A., PhD. | Psychology | Neuroscience of memory & vision |
1968-1973 | Psychology | B.A. (Hon) | Psychology | Psychophysics |
1967-1968 | Carleton University | Qualifying | Physics |
Publications
Treatment of age-related visual impairment with a peptide acting on mitochondria. Alam NM, Douglas RM, Prusky GT.
Dis Model Mech. 2022 Mar 1;15(3):dmm048256. doi: 10.1242/dmm.048256. Epub 2022 Feb 21.
A mitochondrial therapeutic reverses visual decline in mouse models of diabetes. Alam NM, Mills WC 4th, Wong AA, Douglas RM, Szeto HH, Prusky GT.
Dis Model Mech. 2015 Jul 1;8(7):701-10. doi: 10.1242/dmm.020248. Epub 2015 Apr 23.
Photoreceptor regulation of spatial visual behavior. Alam NM, Altimus CM, Douglas RM, Hattar S, Prusky GT. Invest Ophthalmol Vis Sci. 2015 Feb 10;56(3):1842-9. doi: 10.1167/iovs.14-15644.
Experience-enabled enhancement of adult visual cortex function. Tschetter WW, Alam NM, Yee CW, Gorz M, Douglas RM, Sagdullaev B, Prusky GT.
J Neurosci. 2013 Mar 20;33(12):5362-6. doi: 10.1523/JNEUROSCI.5229-12.2013.
Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration in rat models of retinal degenerative disease. McGill TJ, Prusky GT, Douglas RM, Yasumura D, Matthes MT, Lowe RJ, Duncan JL, Yang H, Ahern K, Daniello KM, Silver B, LaVail MM. Invest Ophthalmol Vis Sci. 2012 Sep 14;53(10):6232-44. doi: 10.1167/iovs.12-9569.
Experience-induced interocular plasticity of vision in infancy. Tschetter WW, Douglas RM, Prusky GT. Front Syst Neurosci. 2011 Jun 15;5:44. doi: 10.3389/fnsys.2011.00044. eCollection 2011.
Ruling out and ruling in neural codes. Jacobs AL, Fridman G, Douglas RM, Alam NM, Latham PE, Prusky GT, Nirenberg S. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5936-41. doi: 10.1073/pnas.0900573106. Epub 2009 Mar 18.
Experience-dependent plasticity from eye opening enables lasting, visual cortex-dependent enhancement of motion vision. Prusky GT, Silver BD, Tschetter WW, Alam NM, Douglas RM. J Neurosci. 2008 Sep 24;28(39):9817-27. doi: 10.1523/JNEUROSCI.1940-08.2008.
Intraocular CNTF reduces vision in normal rats in a dose-dependent manner. McGill TJ, Prusky GT, Douglas RM, Yasumura D, Matthes MT, Nune G, Donohue-Rolfe K, Yang H, Niculescu D, Hauswirth WW, Girman SV, Lund RD, Duncan JL, LaVail MM. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5756-66. doi: 10.1167/iovs.07-0054.
Syngeneic Schwann cell transplantation preserves vision in RCS rat without immunosuppression. McGill TJ, Lund RD, Douglas RM, Wang S, Lu B, Silver BD, Secretan MR, Arthur JN, Prusky GT. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1906-12. doi: 10.1167/iovs.06-1117.
Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester. Bennett BM, Reynolds JN, Prusky GT, Douglas RM, Sutherland RJ, Thatcher GR. Neuropsychopharmacology. 2007 Mar;32(3):505-13. doi: 10.1038/sj.npp.1301054. Epub 2006 Mar 8.
Enhancement of vision by monocular deprivation in adult mice. Prusky GT, Alam NM, Douglas RM. J Neurosci. 2006 Nov 8;26(45):11554-61. doi: 10.1523/JNEUROSCI.3396-06.2006.
Perception of visual motion coherence by rats and mice. Douglas RM, Neve A, Quittenbaum JP, Alam NM, Prusky GT. Vision Res. 2006 Sep;46(18):2842-7. doi: 10.1016/j.visres.2006.02.025. Epub 2006 May 2.
Anisomycin activates p38 MAP kinase to induce LTD in mouse primary visual cortex. Xiong W, Kojic LZ, Zhang L, Prasad SS, Douglas R, Wang Y, Cynader MS. Brain Res. 2006 Apr 26;1085(1):68-76. doi: 10.1016/j.brainres.2006.02.015. Epub 2006 Apr 11.
Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual-reality optokinetic system. Douglas RM, Alam NM, Silver BD, McGill TJ, Tschetter WW, Prusky GT. Vis Neurosci. 2005 Sep-Oct;22(5):677-84. doi: 10.1017/S0952523805225166.
Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system. Prusky GT, Alam NM, Beekman S, Douglas RM. Invest Ophthalmol Vis Sci. 2004 Dec;45(12):4611-6. doi: 10.1167/iovs.04-0541.
Characterization of mouse cortical spatial vision. Prusky GT, Douglas RM.
Vision Res. 2004 Dec;44(28):3411-8. doi: 10.1016/j.visres.2004.09.001.
Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex. Prusky GT, Douglas RM, Nelson L, Shabanpoor A, Sutherland RJ. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5064-8. doi: 10.1073/pnas.0308528101. Epub 2004 Mar 29.
Quantification of spatial vision in the Royal College of Surgeons rat. McGill TJ, Douglas RM, Lund RD, Prusky GT. Invest Ophthalmol Vis Sci. 2004 Mar;45(3):932-6. doi: 10.1167/iovs.03-0964.
Preservation of vision following cell-based therapies in a model of retinal degenerative disease. McGill TJ, Lund RD, Douglas RM, Wang S, Lu B, Prusky GT. Vision Res. 2004;44(22):2559-66. doi: 10.1016/j.visres.2004.05.025.
Psychophysical indexes of temporal processing abnormalities in children with developmental dyslexia. Edwards VT, Giaschi DE, Dougherty RF, Edgell D, Bjornson BH, Lyons C, Douglas RM. Dev Neuropsychol. 2004;25(3):321-54. doi: 10.1207/s15326942dn2503_5.
Developmental plasticity of mouse visual acuity. Prusky GT, Douglas RM. Eur J Neurosci. 2003 Jan;17(1):167-73. doi: 10.1046/j.1460-9568.2003.02420.x.
Variation in visual acuity within pigmented, and between pigmented and albino rat strains. Prusky GT, Harker KT, Douglas RM, Whishaw IQ. Behav Brain Res. 2002 Nov 15;136(2):339-48. doi: 10.1016/s0166-4328(02)00126-2.
Laminar distribution of cholinergic- and serotonergic-dependent plasticity within kitten visual cortex. Kojic L, Gu Q, Douglas RM, Cynader MS. Brain Res Dev Brain Res. 2001 Feb 28;126(2):157-62. doi: 10.1016/s0165-3806(00)00146-2.
Reduced visual acuity impairs place but not cued learning in the Morris water task. Prusky GT, West PW, Douglas RM. Behav Brain Res. 2000 Dec 5;116(2):135-40. doi: 10.1016/s0166-4328(00)00267-9.
Experience-dependent plasticity of visual acuity in rats. Prusky GT, West PW, Douglas RM. Eur J Neurosci. 2000 Oct;12(10):3781-6. doi: 10.1046/j.1460-9568.2000.00236.x.
Environmental enrichment from birth enhances visual acuity but not place learning in mice. Prusky GT, Reidel C, Douglas RM. Behav Brain Res. 2000 Sep;114(1-2):11-5. doi: 10.1016/s0166-4328(00)00186-8.
Columnar distribution of serotonin-dependent plasticity within kitten striate cortex. Kojic L, Dyck RH, Gu Q, Douglas RM, Matsubara J, Cynader MS. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1841-4. doi: 10.1073/pnas.97.4.1841.
Behavioral assessment of visual acuity in mice and rats. Prusky GT, West PW, Douglas RM. Vision Res. 2000;40(16):2201-9. doi: 10.1016/s0042-6989(00)00081-x.
Serotonin facilitates synaptic plasticity in kitten visual cortex: an in vitro study. Kojic L, Gu Q, Douglas RM, Cynader MS. Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):299-304. doi: 10.1016/s0165-3806(97)00083-7.
The time course of direction-selective adaptation in simple and complex cells in cat striate cortex. Giaschi D, Douglas R, Marlin S, Cynader M. J Neurophysiol. 1993 Nov;70(5):2024-34. doi: 10.1152/jn.1993.70.5.2024.
Position-specific adaptation in complex cell receptive fields of the cat striate cortex. Marlin S, Douglas R, Cynader M. J Neurophysiol. 1993 Jun;69(6):2209-21. doi: 10.1152/jn.1993.69.6.2209.
Alterations in visual receptive fields in the superior colliculus induced by amphetamine. Grasse KL, Douglas RM, Mendelson JR. Exp Brain Res. 1993;92(3):453-66. doi: 10.1007/BF00229033.
Position-specific adaptation in simple cell receptive fields of the cat striate cortex. Marlin SG, Douglas RM, Cynader MS. J Neurophysiol. 1991 Nov;66(5):1769-84. doi: 10.1152/jn.1991.66.5.1769.
High-frequency discharge of dentate granule cells, but not long-term potentiation, induces c-fos protein. Douglas RM, Dragunow M, Robertson HA. Brain Res. 1988 Nov;464(3):259-62. doi: 10.1016/0169-328x(88)90033-2.
Correlation between long-term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats. Bliss TV, Douglas RM, Errington ML, Lynch MA.J Physiol. 1986 Aug;377:391-408. doi: 10.1113/jphysiol.1986.sp016193.
A time-based stereoscopic depth mechanism in the visual cortex. Gardner JC, Douglas RM, Cynader MS. Brain Res. 1985 Feb 25;328(1):154-7. doi: 10.1016/0006-8993(85)91335-6.
Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades. Guitton D, Buchtel HA, Douglas RM. Exp Brain Res. 1985;58(3):455-72. doi: 10.1007/BF00235863.
Responses of single neurones in cat auditory cortex to time-varying stimuli: frequency-modulated tones of narrow excursion. Phillips DP, Mendelson JR, Cynader MS, Douglas RM. Exp Brain Res. 1985;58(3):443-54. doi: 10.1007/BF00235862.
Eye-head coordination in cats. Guitton D, Douglas RM, Volle M. J Neurophysiol. 1984 Dec;52(6):1030-50. doi: 10.1152/jn.1984.52.6.1030.
Alterations in response properties in the lateral and dorsal terminal nuclei of the cat accessory optic system following visual cortex lesions. Grasse KL, Cynader MS, Douglas RM. Exp Brain Res. 1984;55(1):69-80. doi: 10.1007/BF00240499.
Commissural inhibition and facilitation of granule cell discharge in fascia dentata. Douglas RM, McNaughton BL, Goddard GV. J Comp Neurol. 1983 Sep 20;219(3):285-94. doi: 10.1002/cne.902190304.
Inhibitory modulation of long-term potentiation: evidence for a postsynaptic locus of control. Douglas RM, Goddard GV, Riives M.
Brain Res. 1982 May 27;240(2):259-72. doi: 10.1016/0006-8993(82)90221-9.
A comparison between orienting rapid eye movements accompanying active or passive head movement in the cat. Guitton D, Douglas RM. Rev Can Biol. 1981 Mar;40(1):69-75.
Synaptic enhancement in fascia dentata: cooperativity among coactive afferents. McNaughton BL, Douglas RM, Goddard GV. Brain Res. 1978 Nov 24;157(2):277-93. doi: 10.1016/0006-8993(78)90030-6.
Circadian rhythm of synaptic excitability in rat and monkey central nervous system. Barnes CA, McNaughton BL, Goddard GV, Douglas RM, Adamec R. Science. 1977 Jul 1;197(4298):91-2. doi: 10.1126/science.194313.
Long lasting synaptic potentiation in the rat dentate gyrus following brief high frequency stimulation. Douglas RM. Brain Res. 1977 May 6;126(2):361-5. doi: 10.1016/0006-8993(77)90733-8.
Does the engram of kindling model the engram of normal long term memory? Goddard GV, Douglas RM. Can J Neurol Sci. 1975 Nov;2(4):385-94. doi: 10.1017/s0317167100020539.
Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus. Douglas RM, Goddard GV. Brain Res. 1975 Mar 21;86(2):205-15. doi: 10.1016/0006-8993(75)90697-6.